Cushing’s disease and bipolar disorder: study of medicopsychiatric intricacies from a clinical vignette

Introduction Cushing’s syndrome is a relatively rare condition that results from chronic hypercortisolism. This characterized by the presence of various psychiatric manifestations can accompany it at all its stages evolution. They either inaugurate clinical picture, or appear during course disease, as they persist even after resolution syndrome. Cushing. Through vignette, we report case in 52-year-old patient who presented with picture melancholic depression part bipolar disorder and had preceded discovery disease. Objectives establish relationship between identify main pillars care. Methods It was proposed to present whom psychotic thymic types recall symptoms be encountered such endocrine disorders their possible entanglement pathologies. Results Mrs. F. 52 years old. married mother 3 children, without social security coverage for medullary carcinoma thyroid, having benefited thyroidectomy radiotherapy, admitted treatment paraneoplastic The beginning his troubles goes back 6 months before consultation psychiatry. initial were typical progressive weight gain noticed entourage. There installation an elation mood, self-esteem, multiple projects. One month admission internal medicine department, depressed anhedonia , disgust life, dark thoughts. She stopped drug treatment. disease most common cause endogenous hypercortisolism (>85%). Corticotropic micro-adenomas are frequently observed, i.e., 90% cases, sometimes not visible on magnetic resonance imaging . Its first-line neurosurgical trans-sphenoidal excision. In second intention, uses drugs whose targets pituitary adrenal, well radiotherapy. Conclusions mood Thymic apparent first. hypotheses comorbidity rather inauguration particular disorder, remain advanced limits Disclosure Interest None Declared